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Are Berberine Weight Loss Supplements Effective? [Findings from Important Studies]

by Elwin Robinson
Are Berberine Weight Loss Supplements Effective? [Findings from Important Studies]

Our Berberine Blood Sugar and Weight Loss Support supplement, made with potent Berberis aristata extract, may be effective at helping to regulate blood sugar levels, cholesterol levels, and supporting immune health through berberine’s antioxidant and anti-inflammatory properties.

But can berberine be effective as a weight loss supplement? Let’s investigate some of the science behind the use of berberine supplements and losing weight.

Berberine as a Weight Loss Supplement

Berberine weight loss supplements have been the focus of several studies investigating the nature of berberine’s fat-burning capabilities.

One 2012 study published in Volume 19 (Issue 10) of Phytomedicine focused on the lipid-lowering effects of berberine in rats - and humans.

The study suggested that berberine has lipid-lowering effects both in vitro and in vivo. Pursuant to the study, obese human subjects were administered 500mg doses of berberine three times daily for 12 weeks.

The study tracked body weight, blood lipid levels, and a comprehensive metabolic panel, among other factors. At the end of the study, it was concluded that berberine may be effective at encouraging mild weight loss in obese individuals; participants in the study lost an average of 5 pounds.

The same study indicated that berberine can potentially significantly reduce blood lipid levels in obese individuals as well. Participants experienced a 23% reduction in triglycerides and a 12.2% reduction in cholesterol levels.

A similar study also published in the same edition of Phytomedicine concluded that berberine is also effective at lowering blood lipid levels in rats. Rat test subjects experienced nearly a 35% decrease in blood lipid levels and a slightly less (but still) impressive reduction in overall cholesterol levels, at 9%.

An earlier study (February 2003) focused on the effects of berberine in the differentiation of preadipocytes into adipocytes (fat cells).

Berberine weight loss

The study concluded that while berberine encourages the proliferation of preadipocytes, it actually decreases the terminal differentiation of adipocytes; meaning it discourages, perhaps even suppresses, the formation of “fat cells.” This may potentially make berberine weight loss supplements effective for body mass reduction and weight loss management.

A 2006 study also investigated the effects of berberine on the expression of adipogenic enzymes at the molecular level. The study suggested that berberine extract’s anti-adipogenic (fat-burning) properties are due partly to its ability to down-regulate adipogenic enzymes and transcription factors. That is, berberine may chemically inhibit the formation of fat cells.

Berberine as a weight loss aid is not its only function. It should not be entirely surprising that berberine may also be effective at helping to regulate cholesterol levels in the blood, as cholesterol molecules are lipoproteins and similar to other forms of “fat” molecules.

A 2008 study on the effects of berberine on PCKS9 suggested that it inhibits the enzyme. This is important for several specific reasons.

PCKS9 is a special protein that provides chemical instructions for the production of cholesterol in the body. Specifically, it controls the number of low-density lipoprotein (LDL, or “bad cholesterol) receptors on the body’s cells, which play a vital role in regulating

The 2008 study mentioned above may indicate that berberine’s efficacy in combating LDL in the body is due in part to its inhibition of this enzyme.

In fact, other studies show that berberine may be capable of lowering total blood lipid levels, including triglycerides and total cholesterol. But berberine’s effects are potentially even more beneficial, as it has been found also to raise high-density lipoprotein (HDL, or “good cholesterol”).

HDL is a special type of lipoprotein that can capture other lipids in the blood and transport them back to the liver where they can be flushed from the bloodstream and removed from the body. Higher levels of HDL cholesterol are generally seen as positive as they are associated with lower risks of stroke or heart disease.

This is significant because berberine may pair fat-burning effects with a similarly beneficial effect of lowering LDL and triglyceride levels in the blood while simultaneously boosting HDL levels which makes the body more efficient at purging them.

Berberine as a weight

Blood sugar levels are also tied to the risk and development of obesity. Berberine as a weight loss supplement may also be effective at regulating blood sugar levels in the blood, making it potentially more holistic as a weight loss aid.

Berberine is believed to help regulate blood sugar levels in the body through a series of different mechanisms of action. Berberine has been shown to simultaneously decrease insulin resistance while promoting insulin reduction and to inhibit gluconeogenesis (the production of sugar from non-carbohydrate precursors) in the liver.

Berberine has also been implicated in stimulating glycolysis (the chemical breakdown of glucose molecules, which releases energy and removes glucose from the body); berberine may even inhibit glucose absorption through the intestines.

Additionally, berberine is even involved in the modulation and regulation of flora in the gut, which in turn affects glucose absorption.

Together, these findings indicate that berberine may be potentially effective as a weight loss supplement by inhibiting the production of fat cells, decreasing overall cholesterol levels in the blood, and regulating blood sugar levels.

But there are other potential benefits of berberine supplements as well.

Other Potential Benefits of Berberine Supplements

In addition to berberine’s use as a weight loss supplement, berberine may also be effective at:

  • Supporting overall heart health.
  • Uplifting the mood; select studies in rats suggest that berberine may have antidepressant effects.
  • Fighting inflammation; berberine is a potent antioxidant and anti-inflammatory agent.
  • Berberine may also combat the risk of NAFLD, or Non-Alcoholic Fatty Liver disease, through adipocyte suppression and other fat-fighting mechanisms previously mentioned.
  • Maintaining an optimal metabolism.

Contact Us for Additional Information

Questions about our Berberine Blood Sugar and Weight Loss Support supplement? Contact us at if you have any questions and we will be glad to help.

Otherwise, sign up for our rewards program and try our Berberine supplement; It is made in the U.S.A. and contains no sugar, lactose, gluten, binders, hormones, or antibiotics and it is vegetarian and vegan-friendly.

It’s also earned several 5-star reviews. Check out what our actual customers think about our berberine weight loss supplement via the previous link.